Canine Comparative Oncology & Genomics Consortium

Biospecimen Repository Physical Structure and Procedures

The Pfizer-CCOGC Biospecimen Repository has received support from the intramural National Cancer Institute to establish and maintain a physical bank in Frederick Maryland and to have this bank linked to a web-enabled interface for access to tissues.

The physical bank is managed by Fisher Bioservices and is part of the NCI Frederick Central Repository Services. The facility is over 33,000 sq ft, has 24-hour temperature monitoring, four 250KW generators, and back-up generators. The bank consists of -80C freezers, chemical storage for formalin fixed and paraffin embedded tissues, bar coding hard and soft ware and web enabled sample management system. The bioinformatics platform for the repository includes a relational database that will connect clinical information on samples entered to the study with a front and back end retrieval system. Biological data derived from samples in the Biospecimen Repository are uploaded into the bioinformatics database and become part of the progressive value of the Repository. It is expected that the value of this biological data will exceed the physical value of tissues over time.

The biospecimen repository houses tumor tissue, normal tissues, serum, plasma, peripheral blood mononuclear cell preparations, genomic DNA, RNA and urine samples. Each of the 3000 cases will have tumor and normal tissue collected and processed in both ethanol and two frozen formats (both flash frozen and OCT embedded). The repository follows many parts of the organization and structure of the proposed National Biospecimen Network Blueprint1. Standard operating procedures of tissue/sample collection have been established and are subject to annual review.

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